Paras Kumar Jha

• Lead team of 4 scientists across multiple small-molecule drug discovery programs, driving different inflammatory projects from early screening to mechanistic validation.
• Integrated generative AI tools (e.g., ChatGPT, Perplexity) to streamline experimental planning and optimize protocol development, improving efficiency and scientific rigor.
• Designed, validated, and executed a broad spectrum of in vitro assays targeting diverse signal transduction pathways to support candidate selection and MoA (Mechanism of Action) elucidation.
• Spearheaded Mode of Action studies for novel chemical entities to guide downstream development decisions.
• Collaborated on target identification and validation initiatives, contributing to early-stage pipeline expansion.
• Standardized and validated cell-based assays tailored to in-house discovery programs, ensuring reproducibility and assay robustness.
• Authored and delivered high-impact scientific presentations for both internal strategy meetings and external stakeholders.

• Led a team of 3 senior research associates, driving experimental execution, protocol optimization, and adherence to project timelines.
• Designed and executed cell-based assays (Flow Cytometry, IncuCyte imaging, ELISA, Multiplex) to evaluate bispecific/trispecific antibodies for oncology and autoimmune programs.
• Analyzed and interpreted data using NovoExpress, IncuCyte, and GraphPad Prism, maintaining ALCOA++ compliance.
• Managed cell banking operations (including PBMCs) and oversaw reagent/inventory logistics for client-sponsored studies.
• Developed and standardized in vitro protocols aligned with client goals to support assay development and validation.
• Created data visualizations and scientific reports for internal teams and external stakeholders using Prism, Excel, and PowerPoint.

· Conducted advanced research on T cell, B cell, and NK cell biology, with a focus on immune modulation and therapeutic efficacy.

· · Acted as the in vivo lead for preclinical biologics programs, supporting study design, execution, and translational data analysis.

· · Designed and implemented both ex vivo and in vivo experiments to evaluate cell-mediated immune responses and immunological endpoints.

· · Developed and refined assays/models for efficacy testing, MoA studies, and candidate selection.

· · Collaborated with in vitro experts to analyze flow cytometry data and recommend data-driven next steps.

· · Delivered scientific insights to align project execution with strategic goals.

· · Managed scientific workflows, including coordination of technical teams and study logistics.

· · Performed data analysis and visualization using GraphPad Prism; prepared reports and presentations for cross-functional and external stakeholders.

· Maintained rigorous experimental documentation in line with data integrity and regulatory compliance standards

• Acted as the in vivo representative for preclinical studies in the anti-infective therapeutic area focused on small molecules.
• Developed and optimized in vitro and in vivo models for screening new chemical entities (NCEs), under the mentorship of senior scientists.
• Collaborated cross-functionally with DMPK, medicinal chemistry, and toxicology teams to ensure seamless project execution.
• Authored SOPs and study guidelines, ensuring adherence to institutional and regulatory standards.
• Prepared and defended IAEC (Institutional Animal Ethics Committee) proposals, supporting ethical compliance in animal studies.
• Maintained study documentation in accordance with quality control (QC) and data integrity guidelines.
• Performed pharmacokinetic-pharmacodynamic (PK/PD) studies to assess exposure-response relationships of small molecule candidates under the mentorship of senior scientists.

• Coordinated experimental activities with Senior Research Associates and Research Scientists to ensure smooth project execution.
• Assisted in project design and protocol standardization, contributing to experimental planning and optimization.
• Trained new team members and trainees in laboratory techniques and standard operating procedures.
• Performed routine microbial culture maintenance and ensured the availability and inventory of reagents and consumables.